Surgery of Epilepsy
Pathogenesis of epileptic seizure, The new ways of surgery.
K.V. Khachatryan, A.M.Aydinyan, T.K.Khachatryan
Rationale
Epilepsy remains unsolved problem of modern neurology. This fact has his explanation. The reason is some mistakes in neuroscience. Till now the reticular formation of the brain considered as non specific, activating system and regulator of asleep and awake conditions. It means to say nothing about reticular system. We share the opinion of authors, who think that reticular nuclei are biological accumulators of electricity. This idea was first expressed by Pavlov in 1931. The vision from such imagination can explain many non understandable processes of neuroscience e.g. why we sleep, how brain control different functions, patհogenesis of epilepsy, neurosis etc.
As an biological structure the reticular system also can be subject of damage. We don’t know the nosology due to reticular pathology. For example, what will happen if into accumulators take place “short circuit”? The cortex neurons will depolarize. The depolarization of motor cortex will be expressed as muscle shakes, which clinically appears as tonic seizures. Repolarization of motor cortex can correspond as clonic seizures. Based on this thoughts we proposed the hypothesis of “short circuit” of pathogenesis of epileptic seizures. According to it during an epileptic seizure an outflow of electricity into intercellular space occurs in one of reticular nuclei. The reason of “short circuit” can be damage of myelin layer of reticular cells. Our long term clinical observation led to the idea that myelin layer can be damaged by deformation of brain tissue due to different intracranial pressure into right and left hemispheres of brain. ICP plays an dramatically role of brain functions.
Methods
Our grope have agreement with administration of Institute to organize experiments on dogs. The temporary problems with lowers und ethic comity unsolved yet. The alleged experiment is as follows: To the dog we insert subdural liquid balloon with two external drainage. One of them for checking ICP, second for injection or rejection colored liquor. Enabled EEG monitoring. We increase pressure into balloon and register level of ICP when in EEG appears epileptic waves and level when we observe epileptic seizure. Then we made falxotomy. We repeat experiment. Compare results.
Results
Negative result also result. We hope during annual meeting we will prepare analysis more than ten experiments.
Conclusions
N/A Will be after series of experiments. In case of failure of experiments the idea of new theoretical vision of Epilepsy will be present.
Funding: Please list any funding that was received in support of this abstract.
Will be submit during presentation.